FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term iodotyrosine deiodinase activity ID (Ontology) GO:0140616 (Gene Ontology)
Definition Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates.[ PubMed:15289438 PubMed:18434651 PubMed:25395621 PubMed:27643701 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 iodotyrosine deiodinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | iodotyrosine deiodinase activity
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
  oxidoreductase activity
   |__oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
       |__iodotyrosine deiodinase activity  1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "iodide peroxidase-tyrosine iodinase activity" RELATED
    "iodotyrosine deiodase activity" RELATED
    "monoiodotyrosine deiodinase activity" RELATED
    "tyrosine iodinase activity" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.21.1.1
Reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated"
Reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated"
RHEA:32479