FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term iodotyrosine deiodinase activity ID (Ontology) GO:0140616 (Gene Ontology)
Definition Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates.[ PubMed:15289438 PubMed:18434651 PubMed:25395621 PubMed:27643701 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 iodotyrosine deiodinase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | iodotyrosine deiodinase activity       1
Spanning Tree (Parents/Children)
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  oxidoreductase activity
   |__oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
       |__iodotyrosine deiodinase activity  1 rec.
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Is a oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
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Synonyms
  • "iodide peroxidase-tyrosine iodinase activity" RELATED
    "iodotyrosine deiodase activity" RELATED
    "monoiodotyrosine deiodinase activity" RELATED
    "tyrosine iodinase activity" RELATED
Secondary IDs
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EC:1.21.1.1
Reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated"
Reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated"
RHEA:32479