FB2026_03 , released September 17, 2026
CV Term Report
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Term ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ID (Ontology) GO:0140627 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.[ PubMed:29775578 PubMed:29779948 ]
Also Known As"DesCEND"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (all annotations which use CV term, excluding "NOT" statements)
     involved_in | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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ubiquitin-dependent protein catabolic process__
proteasomal protein catabolic process__________|
                                               proteasome-mediated ubiquitin-dependent protein catabolic process
                                                |__ubiquitin-dependent protein catabolic process via the C-end degron rule pathway  2 rec.
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Is a proteasome-mediated ubiquitin-dependent protein catabolic process
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