FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

cGAS/STING signaling pathway

ID (Ontology)

GO:0140896 (Gene Ontology)

Definition

The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.[ PubMed:27648547 PubMed:34261127 PubMed:34261128 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
cGAS/STING signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| cGAS/STING signaling pathway	--

Spanning Tree (Parents/Children)

pattern recognition receptor signaling pathway__
intracellular receptor signaling pathway________|
                                                cytoplasmic pattern recognition receptor signaling pathway
                                                 |__cGAS/STING signaling pathway  7 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	cytoplasmic pattern recognition receptor signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts