FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone H4 methyltransferase activity ID (Ontology) GO:0140939 (Gene Ontology)
Definition Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue.[ PubMed:28450737 ]
Also Known As"histone H4 methylase activity" ; "histone H4 methylation"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 histone H4 methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H4 methyltransferase activity
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protein methyltransferase activity__
histone modifying activity__________|
                                    histone methyltransferase activity
                                     |__histone H4 methyltransferase activity  7 rec.
                                         |__histone H4K12 methyltransferase activity 1 rec.
                                         |__histone H4K20 methyltransferase activity 4 rec.
                                         |   |__histone H4K20 monomethyltransferase activity 1 rec.
                                         |   |__histone H4K20 trimethyltransferase activity 1 rec.
                                         |   |__histone H4K20me methyltransferase activity 1 rec.
                                         |__histone H4R3 methyltransferase activity 1 rec.
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Is a histone methyltransferase activity
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Synonyms
  • "histone H4 methylase activity" EXACT
    "histone H4 methylation" EXACT
Secondary IDs
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Reactome:R-HSA-5423038 "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)"
Reactome:R-HSA-5651654 "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)"
Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)"