FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone H4K20me methyltransferase activity ID (Ontology) GO:0140941 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethylated lysine residue at position 20 of histone H4, producing H4K20me2.
Also Known As"histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)" ; "histone H4K20me methylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 histone H4K20me methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H4K20me methyltransferase activity
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protein-lysine N-methyltransferase activity__
histone H4 methyltransferase activity________|
                                             histone H4K20 methyltransferase activity
                                              |__histone H4K20me methyltransferase activity  1 rec.
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Is a histone H4K20 methyltransferase activity
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Synonyms
  • "histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)" EXACT
    "histone H4-K20 dimethylation" BROAD
    "histone H4K20 dimethylation" BROAD
    "histone H4K20me methylase activity" EXACT
Secondary IDs
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EC:2.1.1.362
RHEA:60348