FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term very-long-chain 3-oxoacyl-CoA reductase activity ID (Ontology) GO:0141040 (Gene Ontology)
Definition Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.[ PubMed:16564093 PubMed:19763486 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       5
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 Gene Groups Genes
 very-long-chain 3-oxoacyl-CoA reductase activity (all annotations which use CV term, excluding "NOT" statements)       1      5
     enables | very-long-chain 3-oxoacyl-CoA reductase activity       --       5
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__very-long-chain 3-oxoacyl-CoA reductase activity  6 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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EC:1.1.1.330
MetaCyc:RXN-7698
Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA"
RHEA:39267
RHEA:48680
RHEA:85831