FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

protein-glutathione oxidoreductase (glutathione) activity

ID (Ontology)

GO:0141049 (Gene Ontology)

Definition

Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism.[ PubMed:23397885 PubMed:33932870 PubMed:36771108 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
protein-glutathione oxidoreductase (glutathione) activity (all annotations which use CV term, excluding "NOT" statements)
enables \| protein-glutathione oxidoreductase (glutathione) activity	--

Spanning Tree (Parents/Children)

catalytic activity
 |__catalytic activity, acting on a protein_____________________________________________
oxidoreductase activity, acting on a sulfur group of donors                             |
 |__disulfide oxidoreductase activity___________________________________________________|
 |__oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor__|
                                                                                        protein-glutathione oxidoreductase (glutathione) activity  5 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	disulfide oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor catalytic activity, acting on a protein
Part of
Synonyms & Secondary IDs
Synonyms
	"glutaredoxin activity" BROAD "glutathione oxidoreductase activity" BROAD
Secondary IDs

External Crossreferences & Linkouts