FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term diphthine methyl ester synthase activity ID (Ontology) GO:0141133 (Gene Ontology)
Definition Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine.
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 diphthine methyl ester synthase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | diphthine methyl ester synthase activity       1
Spanning Tree (Parents/Children)
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methyltransferase activity
 |__protein methyltransferase activity_________________________
 |__S-adenosylmethionine-dependent methyltransferase activity__|
catalytic activity, acting on a protein                        |
 |__protein methyltransferase activity_________________________|
                                                               diphthine methyl ester synthase activity  1 rec.
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Is a protein methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
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Synonyms
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EC:2.1.1.314
MetaCyc:RXN-15775
Reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2"
RHEA:42652