FB2026_03 , released September 17, 2026
CV Term Report
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Term cAMP/PKA signal transduction ID (Ontology) GO:0141156 (Gene Ontology)
Definition An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell.[ PubMed:23209152 ]
Also Known As"cAMP/PKA signaling cassette"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 cAMP/PKA signal transduction (all annotations which use CV term, excluding "NOT" statements)
     involved_in | cAMP/PKA signal transduction
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  intracellular signal transduction
   |__intracellular signaling cassette
       |__cAMP/PKA signal transduction  9 rec.
           |__regulation of cAMP/PKA signal transduction 8 rec.
               |__negative regulation of cAMP/PKA signal transduction 7 rec.
               |__positive regulation of cAMP/PKA signal transduction 1 rec.
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Is a intracellular signaling cassette
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Synonyms
  • "cAMP signaling" BROAD
    "cAMP/PKA signaling cassette" EXACT
    "PKA signaling" BROAD
    "protein kinase A signaling" BROAD
Secondary IDs
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Reactome:R-HSA-163358 "PKA-mediated phosphorylation of key metabolic factors"