FB2026_03 , released September 17, 2026
CV Term Report
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Term histone deacetylase activity, hydrolytic mechanism ID (Ontology) GO:0141221 (Gene Ontology)
Definition Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].[ PubMed:24691964 PubMed:28450737 ]
Also Known As"histone deacetylase activity, NAD-independent"
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 histone deacetylase activity, hydrolytic mechanism (all annotations which use CV term, excluding "NOT" statements)
     enables | histone deacetylase activity, hydrolytic mechanism       --
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides__
protein lysine deacetylase activity                                                          |
 |__histone deacetylase activity_____________________________________________________________|
histone modifying activity                                                                   |
 |__histone deacetylase activity_____________________________________________________________|
                                                                                         histone deacetylase activity, hydrolytic mechanism  6 rec.
                                                                                          |__histone H3K4 deacetylase activity, hydrolytic mechanism
                                                                                          |__histone H3K9 deacetylase activity, hydrolytic mechanism
                                                                                          |__histone H3K14 deacetylase activity, hydrolytic mechanism
                                                                                          |__histone H4K5 deacetylase activity, hydrolytic mechanism 3 rec.
                                                                                          |__histone H4K8 deacetylase activity, hydrolytic mechanism 3 rec.
                                                                                          |__histone H4K12 deacetylase activity, hydrolytic mechanism 3 rec.
                                                                                          |__histone H4K16 deacetylase activity, hydrolytic mechanism 3 rec.
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Is a histone deacetylase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
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Synonyms
  • "histone deacetylase activity" BROAD
    "histone deacetylase activity, NAD-independent" EXACT
Secondary IDs
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EC:3.5.1.98
MetaCyc:3.5.1.98-RXN
RHEA:58196