FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term histone deacetylase activity, hydrolytic mechanism ID (Ontology) GO:0141221 (Gene Ontology)
Definition Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].[ PubMed:24691964 PubMed:28450737 ]
Also Known As "histone deacetylase activity, NAD-independent"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 histone deacetylase activity, hydrolytic mechanism (all annotations which use CV term, excluding "NOT" statements)       1      2
     enables | histone deacetylase activity, hydrolytic mechanism       --       2
Spanning Tree (Parents/Children)
Only view relationship: 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides__
protein lysine deacetylase activity                                                          |
 |__histone deacetylase activity_____________________________________________________________|
histone modifying activity                                                                   |
 |__histone deacetylase activity_____________________________________________________________|
                                                                                         histone deacetylase activity, hydrolytic mechanism  6 rec.
                                                                                          |__histone H3K4 deacetylase activity, hydrolytic mechanism
                                                                                          |__histone H3K9 deacetylase activity, hydrolytic mechanism
                                                                                          |__histone H3K14 deacetylase activity, hydrolytic mechanism
                                                                                          |__histone H4K5 deacetylase activity, hydrolytic mechanism 3 rec.
                                                                                          |__histone H4K8 deacetylase activity, hydrolytic mechanism 3 rec.
                                                                                          |__histone H4K12 deacetylase activity, hydrolytic mechanism 3 rec.
                                                                                          |__histone H4K16 deacetylase activity, hydrolytic mechanism 3 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a histone deacetylase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "histone deacetylase activity" BROAD
    "histone deacetylase activity, NAD-independent" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.5.1.98
MetaCyc:3.5.1.98-RXN
RHEA:58196