FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term hypoxia-inducible factor-proline dioxygenase activity ID (Ontology) GO:0160082 (Gene Ontology)
Definition Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit].[ PubMed:11595184 PubMed:11598268 ]
Also Known As "HIF prolyl hydroxylase"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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Relevant FlyBase reports
 Genes
 hypoxia-inducible factor-proline dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | hypoxia-inducible factor-proline dioxygenase activity
Spanning Tree (Parents/Children)
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  peptidyl-proline dioxygenase activity
   |__peptidyl-proline 4-dioxygenase activity
       |__hypoxia-inducible factor-proline dioxygenase activity  1 rec.
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Is a peptidyl-proline 4-dioxygenase activity
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Synonyms
  • "HIF hydroxylase" BROAD
    "HIF prolyl hydroxylase" EXACT
Secondary IDs
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EC:1.14.11.29
RHEA:48400