FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tRNA (adenine(58)-N1)-methyltransferase activity ID (Ontology) GO:0160107 (Gene Ontology)
Definition Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine.[ EC:2 ]
Also Known As"tRNA (adenine(58)-N(1))-methyltransferase activity" ; "tRNA (m(1)A(58)) methyltransferase" ; "tRNA m(1)A(58) methyltransferase"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 tRNA (adenine(58)-N1)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA (adenine(58)-N1)-methyltransferase activity
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tRNA methyltransferase activity____________________________
S-adenosylmethionine-dependent methyltransferase activity__|
                                                           tRNA (adenine) methyltransferase activity
                                                            |__tRNA (adenine(58)-N1)-methyltransferase activity  1 rec.
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Synonyms
  • "tRNA (adenine(58)-N(1))-methyltransferase activity" EXACT
    "tRNA (m(1)A(58)) methyltransferase" EXACT
    "tRNA m(1)A(58) methyltransferase" EXACT
Secondary IDs
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EC:2.1.1.220
Reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)"
Reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58"
RHEA:43152