FB2026_03 , released September 17, 2026
CV Term Report
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Term branched-chain alpha-ketoacid dehydrogenase complex ID (Ontology) GO:0160157 (Gene Ontology)
Definition A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.[ PubMed:10464218 PubMed:10745006 PubMed:3593587 ]
Also Known As"BCKD complex" ; "BKDH complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 branched-chain alpha-ketoacid dehydrogenase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | branched-chain alpha-ketoacid dehydrogenase complex       --
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catalytic complex
 |__transferase complex___________________
oxidoreductase complex                    |
 |__alpha-ketoacid dehydrogenase complex__|
                                          branched-chain alpha-ketoacid dehydrogenase complex  6 rec.
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Is a alpha-ketoacid dehydrogenase complex
transferase complex
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  • "BCKD complex" EXACT
    "BKDH complex" EXACT
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Wikipedia:Branched-chain_alpha-keto_acid_dehydrogenase_complex