FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term uniplex complex ID (Ontology) GO:1990246 (Gene Ontology)
Definition A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.[ PubMed:24231807 ]
Also Known As "mitochondrial uniporter complex" ; "mitochondrial uniporter holocomplex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 uniplex complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | uniplex complex       --
 NOT | part_of | uniplex complex       --
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mitochondrial inner membrane
 |__inner mitochondrial membrane protein complex__
cation channel complex                            |
 |__calcium channel complex_______________________|
membrane protein complex                          |
 |__inner mitochondrial membrane protein complex__|
mitochondrial protein-containing complex          |
 |__inner mitochondrial membrane protein complex__|
                                                  uniplex complex  8 rec.
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Is a calcium channel complex
inner mitochondrial membrane protein complex
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Synonyms
  • "mitochondrial uniporter complex" EXACT
    "mitochondrial uniporter holocomplex" EXACT
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