FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term Rhino-Deadlock-Cutoff Complex ID (Ontology) GO:1990469 (Gene Ontology)
Definition Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation.[ PubMed:24906153 ]
Also Known As"RDC complex" ; "rhi-del-cuff complex"
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nucleus
 |__germ cell nucleus___________________
 |__nuclear protein-containing complex__|
protein-containing complex              |
 |__nuclear protein-containing complex__|
 |__PET complex_________________________|
                                        Rhino-Deadlock-Cutoff Complex  1 rec.
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Is a nuclear protein-containing complex
PET complex
Part of germ cell nucleus
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Synonyms
  • "RDC complex" EXACT
    "rhi-del-cuff complex" EXACT
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