FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

HSP90-CDC37 chaperone complex

ID (Ontology)

GO:1990565 (Gene Ontology)

Definition

A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.[ PubMed:21855797 PubMed:22939624 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
HSP90-CDC37 chaperone complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| HSP90-CDC37 chaperone complex

Spanning Tree (Parents/Children)

intracellular anatomical structure
 |__cytoplasm_____________________________
cellular anatomical structure             |
 |__cytoplasm_____________________________|
intracellular protein-containing complex  |
 |__protein folding chaperone complex_____|
                                          HSP90-CDC37 chaperone complex  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein folding chaperone complex
Part of	cytoplasm
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts