FB2026_03 , released September 17, 2026
CV Term Report
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Term regulation of apoptotic signaling pathway ID (Ontology) GO:2001233 (Gene Ontology)
Definition Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.
Also Known As"regulation of apoptotic signalling pathway"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 regulation of apoptotic signaling pathway (all annotations which use CV term, excluding "NOT" statements)
     involved_in | regulation of apoptotic signaling pathway
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apoptotic process
 |__regulation of apoptotic process____
 |__apoptotic signaling pathway________|
signal transduction                    |
 |__regulation of signal transduction__|
 |__apoptotic signaling pathway________|
regulation of cell communication       |
 |__regulation of signal transduction__|
regulation of signaling                |
 |__regulation of signal transduction__|
regulation of programmed cell death    |
 |__regulation of apoptotic process____|
regulation of response to stimulus     |
 |__regulation of signal transduction__|
                                       regulation of apoptotic signaling pathway  29 rec.
                                        |__negative regulation of apoptotic signaling pathway 21 rec.
                                        |   |__negative regulation of apoptosome assembly
                                        |   |__negative regulation of extrinsic apoptotic signaling pathway(+) 2 rec.
                                        |   |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                        |   |__negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 rec.
                                        |   |__negative regulation of release of cytochrome c from mitochondria 2 rec.
                                        |__positive regulation of apoptotic signaling pathway 5 rec.
                                        |   |__positive regulation of extrinsic apoptotic signaling pathway(+)
                                        |   |__positive regulation of intrinsic apoptotic signaling pathway(+) 3 rec.
                                        |__regulation of extrinsic apoptotic signaling pathway 3 rec.
                                        |   |__negative regulation of extrinsic apoptotic signaling pathway(+) 2 rec.
                                        |   |__positive regulation of extrinsic apoptotic signaling pathway(+)
                                        |   |__regulation of extrinsic apoptotic signaling pathway in absence of ligand(+)
                                        |   |__regulation of extrinsic apoptotic signaling pathway via death domain receptors(+) 3 rec.
                                        |__regulation of intrinsic apoptotic signaling pathway 9 rec.
                                            |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                            |__positive regulation of intrinsic apoptotic signaling pathway(+) 3 rec.
                                            |__regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                            |__regulation of hypoxia-induced intrinsic apoptotic signaling pathway(+)
                                            |__regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 3 rec.
                                            |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 3 rec.
                                            |__regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                            |__regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway(+)
                                            |__regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
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Is a regulation of signal transduction
regulation of apoptotic process
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Synonyms
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Reactome:R-HSA-205025 "NADE modulates death signalling"