FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

fluorescence correlation spectroscopy

ID (Ontology)

MI:0052 (Molecular Interactions)

Definition

FCS monitors the random motion of fluorescently labelled molecules inside a defined volume irradiated by a focused laser beam. These fluctuations provide information on the rate of diffusion or diffusion time of a particle and this is directly dependent on the particle mass. As a consequence, any increase in the mass of a biomolecule, e.g. as a result of an interaction with a second molecule, is readily detected as an increase in the diffusion time of the particle. From these results the concentration of the different molecules can be calculated as well as their binding constant.[ PubMed:10733953 ]

Also Known As

"FCS" ; "fcs"

Comment

Links to External Ontologies

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Interaction Groups
fluorescence correlation spectroscopy (all annotations which use CV term, excluding "NOT" statements)

Spanning Tree (Parents/Children)

  biophysical
   |__fluorescence technology
       |__fluorescence correlation spectroscopy  6 rec.

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Relationships
Is a	fluorescence technology
Part of
Synonyms & Secondary IDs
Synonyms
	"FCS" EXACT PSI-MI-alternate "fcs" EXACT PSI-MI-short "fluctuation correlation specctrometry" RELATED
Secondary IDs

External Crossreferences & Linkouts