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General Information
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| Term |
fluorescence correlation spectroscopy |
ID (Ontology) |
MI:0052 (Molecular Interactions) |
| Definition |
FCS monitors the random motion of fluorescently labelled molecules inside a defined volume irradiated by a focused laser beam. These fluctuations provide information on the rate of diffusion or diffusion time of a particle and this is directly dependent on the particle mass. As a consequence, any increase in the mass of a biomolecule, e.g. as a result of an interaction with a second molecule, is readily detected as an increase in the diffusion time of the particle. From these results the concentration of the different molecules can be calculated as well as their binding constant.[ PubMed:10733953 ] |
| Also Known As |
"FCS" ; "fcs" |
| Comment |
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Links to External Ontologies
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Interaction Groups |
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fluorescence correlation spectroscopy (all annotations which use CV term, excluding "NOT" statements) | 6 |
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Relationships