FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

protein_altering_variant

ID (Ontology)

SO:0001818 (Sequence Ontology)

Definition

A sequence_variant which is predicted to change the protein encoded in the coding sequence.

Also Known As

"protein altering variant" ; "VEP:protein_altering_variant"

Comment

Links to External Ontologies

SO.org

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

There are no annotations using this term.

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Alleles
protein_altering_variant (all annotations which use CV term, excluding "NOT" statements)

Spanning Tree (Parents/Children)

exon_variant_______________
coding_transcript_variant__|
                           coding_sequence_variant
                            |__protein_altering_variant  15391 rec.
                                |__frameshift_variant 113 rec.
                                |   |__frame_restoring_variant 1 rec.
                                |   |__frameshift_elongation 2 rec.
                                |   |__frameshift_truncation 43 rec.
                                |   |__frameshift_variant_NMD_escaping
                                |   |__frameshift_variant_NMD_triggering
                                |   |__minus_1_frameshift_variant 1 rec.
                                |   |__minus_2_frameshift_variant
                                |   |__plus_1_frameshift_variant 1 rec.
                                |   |__plus_2_frameshift_variant
                                |__inframe_variant 15252 rec.
                                    |__incomplete_terminal_codon_variant
                                    |__inframe_indel(+) 6403 rec.
                                    |__nonsynonymous_variant(+) 9335 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	coding_sequence_variant
Part of
Synonyms & Secondary IDs
Synonyms
	"protein altering variant" EXACT "VEP:protein_altering_variant" EXACT VAR
Secondary IDs

External Crossreferences & Linkouts
	http:www.ensembl.org/info/genome/variation/predicted_data.html#consequences