Aberration Dmel\Df(2L)Pi3K21B-A

General Information
Symbol	Dmel\Df(2L)Pi3K21B-A	Species	D. melanogaster
Name		FlyBase ID	FBab0028843
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Recent Updates
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FB2011_10
FB2012_01	Genes CR43719
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{lacW}Plc21C^k31911 (Weinkove et al., 1999)
Mutagen	P-element activity (Weinkove et al., 1999)
Class of aberration (relative to progenitor)	chromosomal_deletion
Breakpoints	[];[] (Weinkove et al., 1999)
Causes alleles	Plc21C^A (Weinkove et al., 1999)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Hop (Weinkove et al., 1999) Plc21C (Weinkove et al., 1999) U2af38 (Weinkove et al., 1999)
Molecular Data
Completely deleted	Hop (Weinkove et al., 1999) Pi3K21B (Weinkove et al., 1999) U2af38 (Weinkove et al., 1999)
Partially deleted	Plc21C (Weinkove et al., 1999)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Complements Df(2L)al. (Weinkove et al., 1999)
NOT in combination with other aberrations	Df(2L)Pi3K21B-A/Df(2L)Pi3K21B-B, P{U2af38.gR10} mutants (null for Pi3K21B) stop growing normally early in the third larval instar. Though they continue to move and feed for approximately 20 days they grow very slowly. Larvae are transparent, have small imaginal discs and have reduced fat body. Nervous system, trachea and gut appear normal. Some form pupal cases but show no indication of pupal development. Mutant clones in the eye reveal that Pi3K21B is autonomously required for adult cells to reach their normal size. (Weinkove et al., 1999)
Stocks ( 1 )
Bloomington	25911 w^*; Df(2L)Pi3K21B-A/CyO; P{U2af38.gR10}3
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	18kb deletion extending distally from the site of insertion of the P{lacW} in the progenitor chromosome. (Weinkove et al., 1999)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(2L)p60A (Kain et al., 2008) Df(2L)Pi3K21B-A p60^A (Coelho et al., 2005, Jin et al., 2001, Weinkove et al., 1999, Clancy et al., 2001, Orme et al., 2006) p60A (Miron et al., 2001) Pi3K21B^A
Name Synonym
Secondary FlyBase IDs
	FBal0124096
References ( 8 )
Research paper	Kain et al., 2008, J. Neurosci. 28(18): 4745--4755 Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction. [FBrf0204625] Orme et al., 2006, Nature Cell Biol. 8(11): 1298--1302 Input from Ras is required for maximal PI(3)K signalling in Drosophila. [FBrf0193707] Coelho et al., 2005, Genetics 171(2): 597--614 A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation. [FBrf0190712] Clancy et al., 2001, Science 292(5514): 104--106 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. [FBrf0135946] Jin et al., 2001, Dev. Cell 1(6): 817--827 Regulation of Drosophila tracheal system development by protein kinase B. [FBrf0141466] Miron et al., 2001, Nature Cell Biol. 3(6): 596--601 The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. [FBrf0137059] Weinkove et al., 1999, Curr. Biol. 9(18): 1019--1029 Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. [FBrf0111517]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]