Allele Dmel\vas⁴

General Information
Symbol	Dmel\vas⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0017848
Feature type	allele	Associated gene	Dmel\vas
Also Known As	vas^O11, vas⁰¹¹

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Ashburner et al., 1999.10.12)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:15,072,751..15,072,751 comment=Lasko, 2000.2.7, personal communication evidence=experimental na_change=T15072751A pr_change=I256N\|vas-PA reported_na_change=T?A reported_pr_change=I256N (Liang et al., 1994)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: I256N. (Lasko, 2000.2.1) Nucleotide substitution of AAT for ATT, (amino acid replacement of I by N) in the 425 amino stretch that is highly similar among DEAD-box proteins. (Liang et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| maternal effect \| recessive (Lehmann and Nusslein-Volhard, 1991)
Phenotype Manifest In

Detailed Description
	Statement Reference Absence of posterior pole plasm, polar granules and pole cells. (Lehmann and Nusslein-Volhard, 1991)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Phenotypic data included in FBrf0051973. (Roote, 1995.5.4) Cytoplasmic transplantation of wild type plasm into the abdominal region restores normal abdominal development. (Lehmann and Nusslein-Volhard, 1991)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	vas^0II (Grau and Gutzeit, 1990) vas⁴ vas⁰¹¹ (Cinnamon et al., 2004, Findley et al., 2003, St. Johnston et al., 1991, Lasko and Ashburner, 1990) vas^O11 (Harris and Macdonald, 2001, Liang et al., 1994, Lehmann and Nusslein-Volhard, 1991, Tearle and Nusslein-Volhard, 1987, Anne et al., 2007, Lasko, 2000.2.1, Anne, 2010)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Anne, 2010, Development 137(17): 2819--2828 Arginine methylation of SmB is required for Drosophila germ cell development. [FBrf0211523] Anne et al., 2007, Development 134(1): 137--146 Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. [FBrf0192235] Cinnamon et al., 2004, EMBO J. 23(23): 4571--4582 Capicua integrates input from two maternal systems in Drosophila terminal patterning. [FBrf0180201] Findley et al., 2003, Development 130(5): 859--871 Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. [FBrf0155724] Harris and Macdonald, 2001, Development 128(14): 2823--2832 aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. [FBrf0138362] Liang et al., 1994, Development 120(5): 1201--1211 Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities. [FBrf0073738] Lehmann and Nusslein-Volhard, 1991, Development 112(3): 679--691 The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo. [FBrf0053808] St. Johnston et al., 1991, Cell 66(1): 51--63 staufen, a gene required to localize maternal RNAs in the Drosophila egg. [FBrf0053380] Grau and Gutzeit, 1990, Rouxs Arch. Dev. Biol. 198(5): 295--302 Asymmetrically distributed ecdysteroid-related antigens in follicles and young embryos of Drosophila melanogaster. [FBrf0052916] Lasko and Ashburner, 1990, Genes Dev. 4: 905--921 Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development. [FBrf0051865]
Personal communication to FlyBase	Lasko, 2000.2.1, Question about vasa mutations. Question about vasa mutations. [FBrf0198633] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Roote, 1995.5.4, Genetics 126: 679 help please. Genetics 126: 679 help please. [FBrf0079819]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\vas4

Allele Dmel\vas⁴