FlyBase Allele Report: Dmel\Med[3]

General Information

Symbol

Dmel\Med³

Species

D. melanogaster

Name

FlyBase ID

FBal0044930

Feature type

allele

Associated gene

Dmel\Med

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Horsfield et al., 1998)

Mutagen

ethyl methanesulfonate

(Raftery et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with Med^C246)

(McCabe et al., 2004)

lethal | recessive

(Raftery, 1995.4.6)

lethal - all die before end of pupal stage | recessive

(Raftery et al., 1995)

some die during pupal stage | recessive

(Raftery et al., 1995)

Phenotype Manifest In

bouton (with Med^C246)

(McCabe et al., 2004)

larval central nervous system

(Raftery et al., 1995)

neuromuscular junction (with Med^C246)

(McCabe et al., 2004)

Detailed Description

Statement

Reference

The number of synaptic boutons/muscle surface area at muscle 6/7 in Med³/Med^C246 animals is 38.2 +/- 0.9% of wild type.

(McCabe et al., 2004)

Homozygous third larval instar have variably reduced central nervous systems.

(Raftery et al., 1995)

Lethality occurs during larval and pupal stages.

(Raftery, 1995.4.6)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Med³ is an enhancer of phenotype of dpp^hr4

(Raftery et al., 1995)

Other

Statement

Reference

Med³, dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Med[+]/Med³, dpp^hr4 has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Maternal lethal interaction with dpp^hr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells. dpp^hr4/dpp⁺;Med³/Med⁺ embryos have a partially involuted head skeleton. Embryos exhibits a 'tail up' phenotype, the posterior most structures are pointed more vertically and there is more curvature to the abdominal segments.

(Raftery et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Med^C246/Med³ is rescued by Med^UAS.cSa/Scer\GAL4^elav.PLu

(McCabe et al., 2004)

Not rescued by

Med^C246/Med³ is not rescued by Scer\GAL4^G14/Med^UAS.cSa

(McCabe et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Null allele.

(Horsfield et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Med³

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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