FB2025_01 , released February 20, 2025
Allele: Dmel\UbxIa.UAS.cRa
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General Information
Symbol
Dmel\UbxIa.UAS.cRa
Species
D. melanogaster
Name
FlyBase ID
FBal0103927
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of the Ia isoform of Ubx.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The formation of the most anterior midgut constriction is abnormal in embryos expressing UbxIa.Scer\UAS.cRa under the control of Scer\GAL4how-24B, while the formation of the second and third midgut constrictions is normal.

Expression of UbxIa.Scer\UAS.R under the control of Scer\GAL4sca-109-68 does not result in loss of the apical bristle on the T2 leg. At 18oC, the preapical bristle on T2 is transformed towards the morphology of a T3 preapical bristle (the stout shaft morphology is transformed to a much finer shaft). The short bristles on the T2 basitarsus are transformed towards the long stout morphology of those normally seen on the T3 basitarsus. Expression of UbxIa.Scer\UAS.R under the control of Scer\GAL4dpp.blk1 results in loss of the apical bristle on the T2 leg in 45/50 cases. The preapical bristle is rarely suppressed in these flies (10/50 cases). The mechanosensory microchaetae on the dorsal T2 leg arise normally.

Clones in the wing expressing UbxIa.Scer\UAS.R under the control of Scer\GAL4Act5C.PI and induced at 0-4 hours after puparium formation show no obvious phenotype. Clones in the wing expressing UbxIa.Scer\UAS.R under the control of Scer\GAL4Act5C.PI and induced 48 hours before puparium formation are sometimes transformed to resemble haltere cells, but this transformation is not fully penetrant. Not all clones show any transformation, and even in those that do, not all cells are transformed. Many of the clones have fewer cells than control clones. Clones in the wing expressing UbxIa.Scer\UAS.R under the control of Scer\GAL4Act5C.PI and induced during embryogenesis give rise to large patches of tissue in the wing that differentiate as tissue very similar to the normal haltere.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

H. Reed M. Akam

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
UbxIa.Scer\UAS.R
UbxIa.Scer\UAS.cRa
UbxIa.UAS.cRa
Name Synonyms
Secondary FlyBase IDs
    References (4)