FlyBase Allele Report: Dmel\GIIIspla2[EP1516]

General Information

Symbol

Dmel\GIIIspla2^EP1516

Species

D. melanogaster

Name

FlyBase ID

FBal0131590

Feature type

allele

Associated gene

Dmel\GIIIspla2

Associated Insertion(s)

P{EP}GIIIspla2^EP1516

Carried in Construct

Also Known As

EP(X)1516

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Qurashi et al., 2012)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}GIIIspla2^EP1516

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,157,624..8,157,624 [-]

(Qurashi et al., 2012, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(Qurashi et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

GIIIspla2^EP1516/GIIIspla2[+] is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP

(Qurashi et al., 2012)

NOT Suppressor of

Statement

Reference

GIIIspla2^EP1516/GIIIspla2[+] is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS

(Qurashi et al., 2012)

GIIIspla2^EP1516/GIIIspla2[+] is a non-suppressor of visible | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

GIIIspla2^EP1516/GIIIspla2[+] is a non-suppressor of visible | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

GIIIspla2^EP1516/GIIIspla2[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP

(Qurashi et al., 2012)

GIIIspla2^EP1516 is a suppressor of adult thorax phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

GIIIspla2^EP1516 is a suppressor of mesothoracic cleft | ectopic phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

NOT Suppressor of

Statement

Reference

GIIIspla2^EP1516/GIIIspla2[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS

(Qurashi et al., 2012)

GIIIspla2^EP1516/GIIIspla2[+] is a non-suppressor of eye phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

GIIIspla2^EP1516/GIIIspla2[+] is a non-suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

One copy of GIIIspla2^EP1516 partially suppresses the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GIIIspla2^EP1516 does not suppress the rough eye phenotype seen when Hsap\HTT^{Q128.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GIIIspla2^EP1516 does not suppress the rough eye phenotype seen when Zzzz\CTG^{i480.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GIIIspla2^EP1516 does not suppress the rough eye phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Qurashi et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17006

w¹¹¹⁸ P{EP}GIIIspla2^EP1516 Traf6^EP1516

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG1583^EP1516

(Qurashi et al., 2012)

EP¹⁵¹⁶

(Qurashi et al., 2012)

GIIIspla2^EP1516

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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