FB2025_01 , released February 20, 2025
Allele: Dmel\armS44Y.GMR
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General Information
Symbol
Dmel\armS44Y.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0138353
Feature type
allele
Associated gene
Dmel\arm
Associated Insertion(s)
Carried in Construct
P{GMR-armS44Y}
Key Links
Transgenic product class
missense_variant
(Freeman and Bienz, 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Freeman and Bienz, 2001)
Mutagen
in vitro construct
(Freeman and Bienz, 2001)
Progenitor genotype
Carried in construct
P{GMR-armS44Y}
Cytology
Description

GMR sequences drive expression of a 2.7kb activated form of arm (carries the amino acid replacement S44Y).

(Freeman and Bienz, 2001)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
arm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying armS44Y.GMR have a rough eye phenotype.

      (Morris et al., 2008)

      Flies carrying armS44Y.GMR have eyes which are rough and are smaller than normal.

      (Kankel et al., 2007)

      Homozygous armS44Y.GMR flies have very narrow, rough and glazed eyes. In the eye disc, photoreceptor cell and cone cell recruitment are completely normal, however the retina becomes disorganised losing cone pigment and photoreceptor cells. At later stages the tissue becomes completely disrupted, massive cell death is seen throughout the developing retina.

      (Freeman and Bienz, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      armS44Y.GMR has visible phenotype, enhanceable by mam2/mam[+]

      (Kankel et al., 2007)

      armS44Y.GMR has visible phenotype, enhanceable by mamsAX8/mam[+]

      (Kankel et al., 2007)
      Suppressed by
      Statement
      Reference

      armS44Y.GMR has visible phenotype, suppressible | partially by E2f1UAS.cNa/DpUAS.cDa/Scer\GAL4GMR.PU

      (Morris et al., 2008)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      armS44Y.GMR has eye phenotype, enhanceable by mam2/mam[+]

      (Kankel et al., 2007)

      armS44Y.GMR has eye phenotype, enhanceable by mamsAX8/mam[+]

      (Kankel et al., 2007)
      Suppressed by
      Statement
      Reference

      armS44Y.GMR has eye phenotype, suppressible | partially by E2f1UAS.cNa/DpUAS.cDa/Scer\GAL4GMR.PU

      (Morris et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of E2fScer\UAS.cNa and DpScer\UAS.cDa under the control of Scer\GAL4GMR.PU partially suppresses the rough eye phenotype caused by armS44Y.GMR.

      (Morris et al., 2008)

      The mutant eye phenotype of armS44Y.GMR flies is enhanced by mam2/+ or mamsAX8/+.

      Df(1)N-54l9/+ and N55e11/+ each have little if any effect on the mutant eye phenotype of armS44Y.GMR flies.

      (Kankel et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      armS44Y.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (3)