FlyBase Allele Report: Dmel\Sb[Ebr48]

General Information

Symbol

Dmel\Sb^Ebr48

Species

D. melanogaster

Name

FlyBase ID

FBal0155915

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ward et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | recessive

(Ward et al., 2003)

lethal | larval stage | recessive

(Ward et al., 2003)

Phenotype Manifest In

embryonic/first instar larval cuticle | anterior

(Ward et al., 2003)

Detailed Description

Statement

Reference

Heterozygotes do not show a malformed leg phenotype. Heterozygotes have normal bristle morphology. Homozygotes show 13 +/- 2% embryonic lethality and 91 +/- 5% of homozygous larvae fail to form pupae. 9% of the dead homozygous embryos have a dorsal anterior hole in the cuticle. Homozygotes show larval moulting defects and excessive sclerotisation of the anterior-most cuticle.

(Ward et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sb[+]/Sb^Ebr48 is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

Sb^Ebr48, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Sb^Ebr48, br⁵/br[+] has visible | dominant phenotype

(Ward et al., 2003)

Sb[+]/Sb^Ebr48, br⁵ has visible phenotype

(Ward et al., 2003)

Sb[+]/Sb^Ebr48, zip^Ebr has visible phenotype

(Ward et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sb[+]/Sb^Ebr48 is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

Sb^Ebr48, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr48, br⁵/br[+] has leg phenotype

(Ward et al., 2003)

Sb^Ebr48, br⁵ has leg phenotype

(Ward et al., 2003)

Sb^Ebr48, zip^Ebr has leg phenotype

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

19% of br¹ ; Sb^Ebr48/+ flies show a malformed leg phenotype. The predominant leg phenotype in br¹/Y ; Sb^Ebr48/+ flies is short, fat femurs and tibias. 7% of br⁵/+ ; Sb^Ebr48/+ flies show a malformed leg phenotype. 15% of Sb^Ebr48 Rho1^J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 2% of Sb^Ebr48 Rho1^k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 8% of Sb^Ebr48 Rho1^E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 2% of Sb^Ebr48 RhoGEF2⁰⁴²⁹¹ double heterozygotes show a malformed leg phenotype in at least one leg. 3% of Sb^Ebr48 RhoGEF2^11-3 double heterozygotes show a malformed leg phenotype in at least one leg. 30% of Sb^Ebr48 zip^Ebr double heterozygotes show a malformed leg phenotype in at least one leg. 0% of Sb^Ebr48 zip¹ double heterozygotes show a malformed leg phenotype in at least one leg. 2% of Sb^Ebr48 zip^33-1 double heterozygotes show a malformed leg phenotype in at least one leg.