FlyBase Allele Report: Dmel\Cul3[EY11031]

General Information

Symbol

Dmel\Cul3^EY11031

Species

D. melanogaster

Name

FlyBase ID

FBal0159190

Feature type

allele

Associated gene

Dmel\Cul3

Associated Insertion(s)

P{EPgy2}Cul3^EY11031

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Cul3^EY11031

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:15,271,283..15,271,283 [-]

(Fujiyama-Nakamura et al., 2009, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Cul3^EY11031 mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).

(Neukomm et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Cul3^EY11031 is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Other

Statement

Reference

Cul3^EY11031, Mp^f07253 has abnormal neurophysiology | larval stage phenotype

(Kikuma et al., 2019)

Cul3^EY11031, inc^kk3 has abnormal neurophysiology | larval stage | chemical conditional phenotype

(Kikuma et al., 2019)

Cul3^EY11031, Pef^C295 has abnormal neurophysiology | larval stage | chemical conditional phenotype

(Kikuma et al., 2019)

Cul3^EY11031, Scer\GAL4^pnr-MD237, l(2)37Cb¹ has visible phenotype

(Fujiyama-Nakamura et al., 2009)

CG10324^f06814, Cul3^EY11031, Scer\GAL4^pnr-MD237 has visible phenotype

(Fujiyama-Nakamura et al., 2009)

CG5808^EY13836, Cul3^EY11031, Scer\GAL4^pnr-MD237 has visible phenotype

(Fujiyama-Nakamura et al., 2009)

Cul3^EY11031, Scer\GAL4^pnr-MD237, l(2)37Cb^BG01776 has visible phenotype

(Fujiyama-Nakamura et al., 2009)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Cul3^EY11031 is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Cul3^EY11031 is a non-suppressor of axon | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Other

Statement

Reference

Cul3^EY11031, Scer\GAL4^pnr-MD237, l(2)37Cb¹ has adult external thorax | dorsal phenotype

(Fujiyama-Nakamura et al., 2009)

CG10324^f06814, Cul3^EY11031, Scer\GAL4^pnr-MD237 has adult external thorax | dorsal phenotype

(Fujiyama-Nakamura et al., 2009)

CG5808^EY13836, Cul3^EY11031, Scer\GAL4^pnr-MD237 has adult external thorax | dorsal phenotype

(Fujiyama-Nakamura et al., 2009)

Cul3^EY11031, Scer\GAL4^pnr-MD237, l(2)37Cb^BG01776 has adult external thorax | dorsal phenotype

(Fujiyama-Nakamura et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The axon degeneration in sensory neurons clones in the adult wing expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^VGlut-OK371 can be suppressed by combination with Cul3^EY11031.

(Neukomm et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

20656

y¹ w^67c23; P{EPgy2}Cul3^EY11031

Kyoto

114676

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{EPgy2}Cul3^EY11031 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Cul-3^EY11031

Cul3^EY11031

(Kikuma et al., 2019)

cul-3^EY11031

cul3^EY11031

(Neukomm et al., 2017)

gft^EY11031

(Fujiyama-Nakamura et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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