FB2025_01 , released February 20, 2025
Allele: Dmel\PgiEY09730
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General Information
Symbol
Dmel\PgiEY09730
Species
D. melanogaster
Name
FlyBase ID
FBal0160027
Feature type
allele
Associated gene
Dmel\Pgi
Associated Insertion(s)
P{EPgy2}PgiEY09730
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}PgiEY09730
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cFa
      (Knight et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PgiEY09730/+ mutants exhibit a significant defect in climbing ability, and do not exhibit any significant difference in the number of dopaminergic neurons in newly eclosed adult males, but at 20 days post-eclosion, these flies show a significant decrease in neuron numbers in all dopaminergic neuron clusters, as compared to wild type.

      (Knight et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT suppressed by
      Statement
      Reference

      PgiEY09730 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by chico1/chico[+]

      (Knight et al., 2014)
      Enhancer of
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Statement
      Reference

      PgiEY09730/Pgi[+] is an enhancer of dopaminergic neuron | progressive phenotype of Hsap\SNCAUAS.cFa, Scer\GAL4ple.PF

      (Knight et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      chico1/+ fails to suppress the climbing defects seen in PgiEY09730/+ mutants.

      (Knight et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4ple.PF in PgiEY09730/+ mutants does not lead to any significant difference in the number of dopaminergic neurons in newly eclosed adult males, but these flies show enhanced dopaminergic neuron loss seen at 20 days old as compared to either PgiEY09730/+ mutants or flies expressing Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4ple.PF.

      (Knight et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PgiEY09730
      (Knight et al., 2014)
      PgiΔ
      (Ugrankar et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)