FB2025_01 , released February 20, 2025
Allele: Dmel\eIF4AR321H.UAS
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General Information
Symbol
Dmel\eIF4AR321H.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0191285
Feature type
allele
Associated gene
Dmel\eIF4A
Associated Insertion(s)
Carried in Construct
P{UAS-eIF4A.R321H}
Key Links
Transgenic product class
missense_variant
(Li et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Li et al., 2005)
Mutagen
in vitro construct
(Li et al., 2005)
Progenitor genotype
eIF4AYE9
(Li et al., 2005)
Carried in construct
P{UAS-eIF4A.R321H}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of eIF4A (carries the R321H amino acid replacement, the same lesion as that found in eIF4AYE9).

(Li et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
eIF4A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Df(2L)Gpdh1-A, eIF4AR321H.UAS, Scer\GAL4VP16.mat.αTub67C is a suppressor of lethal | dominant phenotype of dppH46

      (Li et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      eIF-4aR321H.Scer\UAS
      eIF4AR321H.Scer\UAS
      eIF4AR321H.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)