FB2025_01 , released February 20, 2025
Allele: Dmel\SsrpJF02120
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General Information
Symbol
Dmel\SsrpJF02120
Species
D. melanogaster
Name
FlyBase ID
FBal0220609
Feature type
allele
Associated gene
Dmel\Ssrp
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02120}
Also Known As
UAS-SsrpRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.3.31)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.3.31)
Mutagen
in vitro construct
(Perkins et al., 2009.3.31)
Progenitor genotype
Carried in construct
P{TRiP.JF02120}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02120
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SsrpJF02120 in the developing eye under the control of Scer\GAL4Act5C.PI causes severe defects. Male pharate adults fail to eclose, and lack eyes, antennae and head capsules, whereas 5.5% of females hatch and display partial head capsules with absent or small eyes. Consistently, eye-antennal imaginal discs of third instar larvae are significantly smaller.

      (Koltowska et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4unspecified, SsrpJF02120 has decreased cell size | larval stage phenotype, suppressible by ERRUAS.cTa, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has decreased size | larval stage phenotype, suppressible by ERRUAS.cTa, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has short lived phenotype, suppressible | partially by ERRUAS.cTa, Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by ERRUAS.cTa, Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has increased cell number | adult stage phenotype, suppressible | partially by ERRUAS.cTa, Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has decreased cell size | larval stage phenotype, suppressible by MarfTH02740.N, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has decreased cell size | larval stage phenotype, suppressible by Opa1HMS00349, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has decreased cell size | larval stage phenotype, suppressible by mt:CoIITH04769.N/Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has decreased cell size | larval stage phenotype, suppressible by Scer\GAL4unspecified/UQCR-11TH04741.N

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has increased cell number | adult stage phenotype, suppressible by Scer\GAL4wor.PU/UQCR-11TH04741.N

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has increased cell number | adult stage phenotype, suppressible | partially by mt:CoIITH04769.N/Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has decreased size | larval stage phenotype, suppressible | partially by mt:CoIITH04769.N/Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has short lived phenotype, suppressible | partially by mt:CoIITH04769.N/Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has short lived phenotype, suppressible | partially by Scer\GAL4wor.PU/UQCR-11TH04741.N

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by mt:CoIITH04769.N/Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Scer\GAL4wor.PU/UQCR-11TH04741.N

      (Lou et al., 2024)

      Scer\GAL4Act5C.PI, SsrpJF02120 has lethal - all die during pharate adult stage phenotype, suppressible by Drer\ssrp1aUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has lethal - all die during pharate adult stage phenotype, suppressible by Drer\ssrp1bUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has lethal - all die during pharate adult stage phenotype, suppressible by Drer\ssrp1a1-518.UAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)
      NOT suppressed by
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4unspecified, SsrpJF02120 has larval neuroblast phenotype, suppressible by ERRUAS.cTa, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has larval brain phenotype, suppressible by ERRUAS.cTa, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has neuroblast | ectopic | adult stage phenotype, suppressible | partially by ERRUAS.cTa, Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has larval neuroblast phenotype, suppressible by MarfTH02740.N, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has larval neuroblast phenotype, suppressible by Opa1HMS00349, Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has larval neuroblast phenotype, suppressible by mt:CoIITH04769.N/Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has larval neuroblast phenotype, suppressible by Scer\GAL4unspecified/UQCR-11TH04741.N

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has neuroblast | ectopic | adult stage phenotype, suppressible by Scer\GAL4wor.PU/UQCR-11TH04741.N

      (Lou et al., 2024)

      Scer\GAL4wor.PU, SsrpJF02120 has neuroblast | ectopic | adult stage phenotype, suppressible | partially by mt:CoIITH04769.N/Scer\GAL4wor.PU

      (Lou et al., 2024)

      Scer\GAL4unspecified, SsrpJF02120 has larval brain phenotype, suppressible | partially by mt:CoIITH04769.N/Scer\GAL4unspecified

      (Lou et al., 2024)

      Scer\GAL4Act5C.PI, SsrpJF02120 has eye phenotype, suppressible by Drer\ssrp1aUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has antenna phenotype, suppressible by Drer\ssrp1aUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has adult head capsule phenotype, suppressible by Drer\ssrp1aUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has eye-antennal disc phenotype, suppressible by Drer\ssrp1aUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has eye phenotype, suppressible by Drer\ssrp1bUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has antenna phenotype, suppressible by Drer\ssrp1bUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has adult head capsule phenotype, suppressible by Drer\ssrp1bUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has eye-antennal disc phenotype, suppressible by Drer\ssrp1bUAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has eye phenotype, suppressible by Drer\ssrp1a1-518.UAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has antenna phenotype, suppressible by Drer\ssrp1a1-518.UAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has adult head capsule phenotype, suppressible by Drer\ssrp1a1-518.UAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)

      Scer\GAL4Act5C.PI, SsrpJF02120 has eye-antennal disc phenotype, suppressible by Drer\ssrp1a1-518.UAS.Tag:V5, Scer\GAL4Act5C.PI

      (Koltowska et al., 2013)
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Drer\ssrp1aScer\UAS.T:SV5\V5 with SsrpJF02120, under the control of Scer\GAL4Act5C.PI, rescues the severe defects found in developing flies expressing SsrpJF02120. The majority of adult females and males hatch and display normal heads and eyes.

      Co-expression of Drer\ssrp1bScer\UAS.T:SV5\V5 with SsrpJF02120, under the control of Scer\GAL4Act5C.PI, rescues the severe defects found in developing flies expressing SsrpJF02120. Adults of these mutants exhibit slightly rough eyes. Proliferation and R-cell differentiation in eye-antennal discs are indistinguishable from controls.

      Co-expression of Drer\ssrp1a1-518.Scer\UAS.T:SV5\V5 with SsrpJF02120, under the control of Scer\GAL4Act5C.PI, rescues the severe defects found in developing flies expressing SsrpJF02120. Adults of these mutants exhibit slightly rough eyes. Proliferation and R-cell differentiation in eye-antennal discs are indistinguishable from controls.

      Co-expression of Drer\ssrp1as819.Scer\UAS.T:SV5\V5 with SsrpJF02120, under the control of Scer\GAL4Act5C.PI, does not rescue the severe defects found in developing flies expressing SsrpJF02120.

      (Koltowska et al., 2013)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SsrpJF02120
      Name Synonyms
      Secondary FlyBase IDs
        References (6)