FlyBase Allele Report: Dmel\Thor[TA.UAS]

General Information

Symbol

Dmel\Thor^TA.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0220792

Feature type

allele

Associated gene

Dmel\Thor

Associated Insertion(s)

Carried in Construct

P{UAS-Thor.TA}

Also Known As

UAS-4E-BP^TA

Key Links

Transgenic product class

missense_variant

(Imai et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Imai et al., 2008)

Mutagen

in vitro construct

(Imai et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-Thor.TA}

Cytology

Description

Amino acid replacement: T37A.

(Imai et al., 2008)

UAS regulatory sequences drive expression of a mutated form of Thor.

(Imai et al., 2008)

Amino acid replacement: T46A.

(Imai et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Thor

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Lrrk^I1915T.UAS

(Imai et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^Mhc.PW

(Lee et al., 2010)

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PU

(Niehues et al., 2015)

abnormal neuroanatomy | larval stage, with Scer\GAL4^VGlut1-OK371

(Niehues et al., 2015)

Phenotype Manifest In

embryonic/larval neuromuscular junction, with Scer\GAL4^VGlut1-OK371

(Niehues et al., 2015)

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^ppk.PU

(Niehues et al., 2015)

type I bouton, with Scer\GAL4^Mhc.PW

(Lee et al., 2010)

Detailed Description

Statement

Reference

Scer\GAL4^VGlut-OK371-mediated expression in motor neurons results in muscle 24 denervation in the vast majority of larvae.

Scer\GAL4^ppk.PU-mediated expression in class IV multidendritic sensory neurons induces severe morphology defects, with reduction of dendritic coverage by around 40%.

(Niehues et al., 2015)

Post-synaptic expression of Thor^TA.Scer\UAS under the control of Scer\GAL4^Mhc.PW leads to a decrease in the total number of type I boutons (both type Ib and type Is) on muscle 6/7 of A3. Presynaptic expression of Thor^TA.Scer\UAS (under the control of Scer\GAL4^elav-C155) has no effect.

(Lee et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Thor^TA.UAS, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Lrrk^I1915T.UAS, Scer\GAL4^elav-C155

(Imai et al., 2008)

NOT Suppressor of

Statement

Reference

Thor^TA.UAS/Scer\GAL4^e22c is a non-suppressor of increased cell death phenotype of Scer\GAL4^e22c, hppy^UAS.cLa

(Lam et al., 2010)

Thor^TA.UAS, Scer\GAL4^Mhc.PW is a non-suppressor of abnormal neuroanatomy phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Lee et al., 2010)

Thor^TA.UAS/Scer\GAL4^Mhc.PW is a non-suppressor of abnormal neuroanatomy phenotype of Lrrk^UAS.cIa, Scer\GAL4^elav-C155

(Lee et al., 2010)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Thor^TA.UAS/Scer\GAL4^e22c is a non-suppressor of wing phenotype of Scer\GAL4^e22c, hppy^UAS.cLa

(Lam et al., 2010)

Thor^TA.UAS/Scer\GAL4^e22c is a non-suppressor of wing margin bristle phenotype of Scer\GAL4^e22c, hppy^UAS.cLa

(Lam et al., 2010)

Thor^TA.UAS/Scer\GAL4^e22c is a non-suppressor of wing vein phenotype of Scer\GAL4^e22c, hppy^UAS.cLa

(Lam et al., 2010)

Thor^TA.UAS, Scer\GAL4^Mhc.PW is a non-suppressor of neuromuscular junction phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Lee et al., 2010)

Thor^TA.UAS/Scer\GAL4^Mhc.PW is a non-suppressor of neuromuscular junction phenotype of Lrrk^UAS.cIa, Scer\GAL4^elav-C155

(Lee et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Thor^TA.Scer\UAS under the control of Scer\GAL4^e22c does not affect cell death in the posterior compartment of the wing discs seen upon expression of hppy^Scer\UAS.cLa.

(Lam et al., 2010)

The reduction of neuromuscular junctions caused by post-synaptic expression of Lrrk^Scer\UAS.cIa (under the control of Scer\GAL4^Mhc.PW) is unaffected by the coexpression of Thor^TA.Scer\UAS.

Coexpression of Thor^TA.Scer\UAS in the post-synaptic compartment under the control of Scer\GAL4^Mhc.PW is unable to rescue the neuromuscular junction phenotype caused by presynaptic Lrrk^Scer\UAS.cIa expression (under the control of Scer\GAL4^elav-C155.

(Lee et al., 2010)

The reduced climbing ability that is seen in 45 day old flies expressing Lrrk^{I1915T.Scer\UAS} under the control of Scer\GAL4^elav-C155 is partially rescued by co-expression of Thor^TA.Scer\UAS.

(Imai et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

The increased sensitivity of Thor^k13517 flies to paraquat and to hydrogen peroxide is rescued by expression of Thor^TA.Scer\UAS under the control of Scer\GAL4^da.G32 and in fact the rescued flies show increased resistance to paraquat and to hydrogen peroxide compared to controls.

(Imai et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Thor^TA.Scer\UAS

Thor^TA.UAS

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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