FlyBase Allele Report: Dmel\ATP7[KK100396]

General Information

Symbol

Dmel\ATP7^KK100396

Species

D. melanogaster

Name

FlyBase ID

FBal0230719

Feature type

allele

Associated gene

Dmel\ATP7

Associated Insertion(s)

Carried in Construct

P{KK100396}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100396}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100396

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of metal metabolism disorder

CEA

(Hartwig et al., 2021, Zlatic et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

Phenotype Manifest In

adult abdomen, with Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

adult thorax, with Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

Detailed Description

Statement

Reference

Expression of ATP7^KK100396 under the control of Scer\GAL4^pnr-MD237 leads to hypopigmentation on the abdomen and thorax when compared to control adults.

(Zhang et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

ATP7^KK100396, Scer\GAL4^pnr-MD237 has visible | adult stage phenotype, non-enhanceable by slmb^UAS.cGa, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^pnr-MD237 has visible | adult stage phenotype, non-enhanceable by slmb^GD10682, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

NOT suppressed by

Statement

Reference

ATP7^KK100396, Scer\GAL4^pnr-MD237 has visible | adult stage phenotype, non-suppressible by slmb^UAS.cGa, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^pnr-MD237 has visible | adult stage phenotype, non-suppressible by slmb^GD10682, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

Suppressor of

Statement

Reference

ATP7^KK100396, Scer\GAL4^GMR.PFa is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, slmb^GD10682

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^pnr-MD237 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^pnr-MD237, slmb^GD10682

(Zhang et al., 2020)

NOT Suppressor of

Statement

Reference

ATP7^KK100396, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, cnc^{UAS.ORF.GW.Tag:HA}

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^GMR.PFa is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.PFa, cnc^{UAS.ORF.GW.Tag:HA}

(Zhang et al., 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

ATP7^KK100396, Scer\GAL4^pnr-MD237 has adult thorax phenotype, non-enhanceable by slmb^UAS.cGa, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^pnr-MD237 has adult thorax phenotype, non-enhanceable by slmb^GD10682, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

NOT suppressed by

Statement

Reference

ATP7^KK100396, Scer\GAL4^pnr-MD237 has adult thorax phenotype, non-suppressible by slmb^UAS.cGa, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^pnr-MD237 has adult thorax phenotype, non-suppressible by slmb^GD10682, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

Suppressor of

Statement

Reference

ATP7^KK100396, Scer\GAL4^pnr-MD237 is a suppressor | partially of adult thorax phenotype of Scer\GAL4^pnr-MD237, slmb^GD10682

(Zhang et al., 2020)

ATP7^KK100396, Scer\GAL4^GMR.PFa is a suppressor of eye phenotype of Scer\GAL4^GMR.PFa, slmb^GD10682

(Zhang et al., 2020)

NOT Suppressor of

Statement

Reference

ATP7^KK100396, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PFa, cnc^{UAS.ORF.GW.Tag:HA}

(Zhang et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Thoracic cleft but not hypopigmentation on thorax phenotype resulted from the expression of slmb^GD10682 (under the control of Scer\GAL4^pnr-MD237) is suppressible by expression of ATP7^KK100396 (under the control of Scer\GAL4^pnr-MD237).

(Zhang et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108159

P{KK100396}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ATP7^KK100396

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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