FlyBase Allele Report: Dmel\Cubn[JF03118]

General Information

Symbol

Dmel\Cubn^JF03118

Species

D. melanogaster

Name

FlyBase ID

FBal0239618

Feature type

allele

Associated gene

Dmel\Cubn

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03118}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03118}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03118

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of kidney disease

CEA

(Xi et al., 2024)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

increased speed of aging, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

short lived, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021, Fu et al., 2017)

Phenotype Manifest In

adult brain, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

indirect flight muscle cell, with Scer\GAL4^Ugt36A1.PK

(Feng et al., 2021)

nephrocyte | larval stage, with Scer\GAL4^sns.PU

(Xi et al., 2024)

nephrocyte diaphragm | larval stage, with Scer\GAL4^sns.PU

(Xi et al., 2024)

Detailed Description

Statement

Reference

Adult flies expressing Cubn^JF03118 under the control of Scer\GAL4^Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

(Fu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Cubn^JF03118, Scer\GAL4^sns.PU has nephrocyte | larval stage phenotype, suppressible | partially by G6pd^UAS.cLa, Scer\GAL4^sns.PU

(Xi et al., 2024)

Cubn^JF03118, Scer\GAL4^sns.PU has nephrocyte diaphragm | larval stage phenotype, suppressible | partially by G6pd^UAS.cLa, Scer\GAL4^sns.PU

(Xi et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28702

y¹ v¹; P{TRiP.JF03118}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG32702^JF03118

Cubn^JF03118

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close