FB2025_01 , released February 20, 2025
Allele: Dmel\CrebBJF02494
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General Information
Symbol
Dmel\CrebBJF02494
Species
D. melanogaster
Name
FlyBase ID
FBal0242176
Feature type
allele
Associated gene
Dmel\CrebB
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02494}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02494}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02494
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Huntington's disease
      modeled by Hsap\HTTN548.Q128.UAS
      (Martin et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of CrebBJF02494 for 2 days during adulthood under the control Scer\GAL4ey-OK107 (in combination with Gal80[ts], for the temporal control of expression) induces a significant decrease in 24h olfactory memory, but not in learning, upon an olfactory aversive conditioning assay, as compared to controls; however, there are no effects in residual olfactory memory upon cold-shock, as compared to controls.

      (Lee et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      CrebBJF02494, Scer\GAL4repo.Switch.2301 is an enhancer of short lived | RU486 conditional phenotype of Hsap\HTTN548.Q128.UAS, Scer\GAL4repo.Switch.2301

      (Martin et al., 2021)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CrebB-17AJF02494
      CrebBJF02494
      Name Synonyms
      Secondary FlyBase IDs
        References (11)