FlyBase Allele Report: Dmel\nudC[HMS00258]

General Information

Symbol

Dmel\nudC^HMS00258

Species

D. melanogaster

Name

FlyBase ID

FBal0257159

Feature type

allele

Associated gene

Dmel\nudC

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00258}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00258}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00258

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^unspecified

(Wang et al., 2015)

Phenotype Manifest In

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Ke et al., 2018)

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Ke et al., 2018)

larval multidendritic class I neuron, with Scer\GAL4^unspecified

(Wang et al., 2015)

Detailed Description

Statement

Reference

The expression of nudC^HMS00258 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

(Ke et al., 2018)

Expression of nudC^HMS00258 (under the control of Scer\GAL4^unspecified) causes Class I dendritic arborizing neurons to assume bipolar morphology, but dendritic arborization is unaffected.

(Wang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^eve.RN2/nudC^HMS00258 is a suppressor | partially of neurite | increased number phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

Scer\GAL4^eve.RN2/nudC^HMS00258 is a suppressor | partially of dendrite | increased number phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

Scer\GAL4^eve.RN2/nudC^HMS00258 is a suppressor | partially of embryonic/larval motor neuron phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of nudC^HMS00258 partially rescues the supernumerary dendrite phenotype seen in animals expressing dar1^Scer\UAS.cYa under the control of Scer\GAL4^eve.RN2 (in unipolar motor neurons).

(Wang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33382