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General Information
Symbol
Dmel\KankHMS00319
Species
D. melanogaster
Name
FlyBase ID
FBal0257209
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a short inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Adult flies expressing KankHMS00319 under the control of Scer\GAL4Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.
Expression of KankHMS00319 under the control of Scer\GAL4Dot.PU in larvae results in impaired nephrocyte function as assayed by fluorescent protein uptake, but no change in number or size of cardiac nephrocytes. Expression of KankHMS00319 under the control of Scer\GAL4Dot.PU results in uneven distribution of endocytic vacuoles and lacuna channels, diminished and abnormally shaped lacuna structures, and a reduced number of vacuoles and lysosomes in cardiac nephrocytes; uneven cell surfaces and gaps between the plasma membrane and the basement membrane of nephrocytes, and absent slit diaphragm filtration structures of the nephrocytes of third instar larvae, as compared to wild type.
Scer\GAL4en-e16E-mediated expression does not significantly change the size of the posterior compartment of the adult wing.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG10249HMS00319
KankHMS00319
Name Synonyms
Secondary FlyBase IDs
    References (4)