FlyBase Allele Report: Dmel\lace[KK102282]

General Information

Symbol

Dmel\lace^KK102282

Species

D. melanogaster

Name

FlyBase ID

FBal0259144

Feature type

allele

Associated gene

Dmel\lace

Associated Insertion(s)

Carried in Construct

P{KK102282}

Also Known As

lace RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102282}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102282

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Friedreich ataxia

modeled by fh¹

(Chen et al., 2016)

ameliorates Parkinson's disease 14

modeled by iPLA2-VIA^Δ174

(Lin et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PI/lace^KK102282 is a suppressor | partially of bang sensitive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Scer\GAL4^Act5C.PI/lace^KK102282 is a suppressor of abnormal neurophysiology | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Scer\GAL4^Act5C.PI/lace^KK102282 is a suppressor of decreased cell number | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

lace^KK102282/Scer\GAL4^ninaE.PT is a suppressor | partially of abnormal neurophysiology | somatic clone | adult stage phenotype of fh¹

(Chen et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PI/lace^KK102282 is a suppressor of retina | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Scer\GAL4^Act5C.PI/lace^KK102282 is a suppressor of eye photoreceptor cell | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

lace^KK102282/Scer\GAL4^ninaE.PT is a suppressor | partially of eye photoreceptor cell | somatic clone | adult stage phenotype of fh¹

(Chen et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of lace^KK102282 under the control of Scer\GAL4^ninaE.PT partially rescues the neurodegeneration and electrophysiology defect seen in fh¹ mutant photoreceptor clones.

(Chen et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110181

P{KK102282}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lace^KK102282

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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