FlyBase Allele Report: Dmel\Hs3st-B[KK108793]

General Information

Symbol

Dmel\Hs3st-B^KK108793

Species

D. melanogaster

Name

FlyBase ID

FBal0259729

Feature type

allele

Associated gene

Dmel\Hs3st-B

Associated Insertion(s)

Carried in Construct

P{KK108793}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108793}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108793

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hs3st-B^KK108793, Scer\GAL4^repo.PU is a suppressor | partially of lethal - all die during P-stage phenotype of Scer\GAL4^repo.PU, Snr1^KK101602

(Tegeder et al., 2019)

Scer\GAL4^Ras64B.PW/Hs3st-B^KK108793 is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

Hs3st-B^KK108793/Scer\GAL4^C23 is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^repo/Hs3st-B^KK108793 is a non-suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

Other

Statement

Reference

Hs3st-B^KK108793, Scer\GAL4^repo.PU, Snr1^KK101602 has partially lethal - majority die phenotype

(Tegeder et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Hs3st-B^KK108793 under the control of either Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of Scer\GAL4^repo has no significant effect.

(Walker et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110601

P{KK108793}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hs3st-B^KK108793

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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