FB2025_01 , released February 20, 2025
Allele: Dmel\Sersec.UAS
Open Close
General Information
Symbol
Dmel\Sersec.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0285278
Feature type
allele
Associated gene
Dmel\Ser
Associated Insertion(s)
Carried in Construct
P{UAS-Ser.sec}
Also Known As
Sersec
Key Links
Transgenic product class
inframe_deletion
(Fleming et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Fleming et al., 2013)
Mutagen
in vitro construct
(Fleming et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Ser.sec}
Cytology
Description

UASt regulatory sequences drive expression of an secreted, extracellular form of Ser encoding all 14 EGF-like repeats plus an additional 72 amino acid residues.

(Fleming et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ser
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sersec.Scer\UAS under the control of Scer\GAL4Ser.PGF results in a rudimentary wing with exaggerated wing venation.

      (Fleming et al., 2013)

      Expression of Sersec.Scer\UAS in the glia (under the control of Scer\GAL4C855a) causes a marked advance of the proneural wave.

      Expression of Sersec.Scer\UAS in the glia (under the control of Scer\GAL4repo.PU) leads to a significant decrease in the number of repo-positive and phospho-His3-positive cells (indicative of mitosis), compared to control optic lobes.

      (Pérez-Gómez et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Sersec.UAS, Scer\GAL4repo.PU is a suppressor of glial cell phenotype of Nint.U.UAS, Scer\GAL4repo.PU

      (Pérez-Gómez et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sersec.Scer\UAS
      Sersec.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)