FB2025_01 , released February 20, 2025
Allele: Dmel\hiw052
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General Information
Symbol
Dmel\hiw052
Species
D. melanogaster
Name
FlyBase ID
FBal0297418
Feature type
allele
Associated gene
Dmel\hiw
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Neukomm et al., 2014)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Neukomm et al., 2014)

Amino acid replacement: Q2791term.

(Neukomm et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,018,906..15,018,906 [-]
Nucleotide change:

C15018906T

Reported nucleotide change:

C?T

Amino acid change:

Q2791term | hiw-PA; Q2791term | hiw-PB

Reported amino acid change:

Q2791term

(Neukomm et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hiw052 has a strong protective effect on L1 vein neurons following axotomy. Whereas wild type axons undergo fragmentation, many severed but intact axons are observed. A similar protective effect is seen in axotomised olfactory receptor neurons.

      hiw052/hiwΔN has a strong protective effect on L1 vein neurons following axotomy. Whereas wild type axons undergo fragmentation, many severed but intact axons are observed. A similar protective effect is seen in axotomised olfactory receptor neurons.

      (Neukomm et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      hiw052 is rescued by Scer\GAL4VGlut1-OK371/hiwUAS.fl

      (Neukomm et al., 2014)

      hiw052 is rescued by Scer\GAL4VGlut1-OK371/hiwUAS.W.EGFP

      (Neukomm et al., 2014)
      Comments

      Expression of hiwScer\UAS.fl under the control of Scer\GAL4VGlut-OK371 suppresses the strong protective effect of hiw052 on L1 vein neurons following axotomy. As in wild type, the severed axons undergo fragmentation.

      Expression of hiwScer\UAS.W.T:Avic\GFP-EGFP under the control of Scer\GAL4VGlut-OK371 suppresses the strong protective effect of hiw052 on L1 vein neurons following axotomy. As in wild type, the severed axons undergo fragmentation.

      (Neukomm et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hiw052
      (Neukomm et al., 2014)
      x052
      (Neukomm et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)