FB2025_01 , released February 20, 2025
Allele: Dmel\axedMI13270
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General Information
Symbol
Dmel\axedMI13270
Species
D. melanogaster
Name
FlyBase ID
FBal0298247
Feature type
allele
Associated gene
Dmel\axed
Associated Insertion(s)
Mi{MIC}axedMI13270
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}axedMI13270
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies carrying axedMI13270 mutant somatic clones show defective injury-induced axon degeneration: severed axons in sensory neurons in the adult wing remain intact for a full week after an axotomy, instead of being cleared away.

        (Neukomm et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        axed0011

        (Neukomm et al., 2017)

        axed2094

        (Neukomm et al., 2017)
        Rescued by

        axedMI13270 is rescued by Scer\GAL4VGlut1-OK371/axedUAS.long

        (Neukomm et al., 2017)
        Partially rescued by

        axedMI13270 is partially rescued by Scer\GAL4VGlut1-OK371/axedΔBTB.UAS

        (Neukomm et al., 2017)

        axedMI13270 is partially rescued by axedΔBACK.UAS/Scer\GAL4VGlut1-OK371

        (Neukomm et al., 2017)
        Not rescued by

        axedMI13270 is not rescued by axedΔCterm.UAS/Scer\GAL4VGlut1-OK371

        (Neukomm et al., 2017)
        Comments

        The defective injury-induced axon degeneration observed in flies carrying axedMI13270 mutant neural clones (severed axons in sensory neurons in the adult wing remain intact following an axotomy, instead of being cleared away) can be rescued by clonal Scer\GAL4VGlut-OK371-driven expression of any of the following: axedScer\UAS.long, axedΔBTB.Scer\UAS, axedΔBACK.Scer\UAS or axedΔCterm.Scer\UAS.

        (Neukomm et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG8398MI13270
        (Neukomm et al., 2017, Bellen, 2014.9.2)
        axedMI13270
        (Neukomm et al., 2017)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)