FlyBase Allele Report: Dmel\axed[UAS.long]

General Information

Symbol

Dmel\axed^UAS.long

Species

D. melanogaster

Name

FlyBase ID

FBal0327545

Feature type

allele

Associated gene

Dmel\axed

Associated Insertion(s)

Carried in Construct

P{UAS-axed.long}

Key Links

Transgenic product class

cDNA

(Neukomm et al., 2017)

wild_type

(Neukomm et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Neukomm et al., 2017)

wild_type

(Neukomm et al., 2017)

Mutagen

in vitro construct

(Neukomm et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-axed.long}

Cytology

Description

UAS regulatory sequences drive expression of axed cDNA (the long isoform), including endogenous 5' and 3' UTRs.

(Neukomm et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

axed

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^455.2

(Izadifar et al., 2021)

Phenotype Manifest In

adult mechanosensory neuron, with Scer\GAL4^455.2

(Izadifar et al., 2021)

axon | adult stage, with Scer\GAL4^455.2

(Izadifar et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^455.2, axed^UAS.long has abnormal neuroanatomy | adult stage phenotype, suppressible by Scer\GAL4^455.2/Wnk^UAS.cIa

(Izadifar et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^455.2, axed^UAS.long has axon | adult stage phenotype, suppressible by Scer\GAL4^455.2/Wnk^UAS.cIa

(Izadifar et al., 2021)

Scer\GAL4^455.2, axed^UAS.long has adult mechanosensory neuron phenotype, suppressible by Scer\GAL4^455.2/Wnk^UAS.cIa

(Izadifar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^VGlut1-OK371/axed^UAS.long rescues axed⁰⁰¹¹

(Neukomm et al., 2017)

Scer\GAL4^VGlut1-OK371/axed^UAS.long rescues axed²⁰⁹⁴

(Neukomm et al., 2017)

Scer\GAL4^VGlut1-OK371/axed^UAS.long rescues axed^MI13270

(Neukomm et al., 2017)

Comments

The defective injury-induced axon degeneration observed in flies carrying axed⁰⁰¹¹, axed²⁰⁹⁴ or axed^MI13270 mutant neural clones (severed axons in sensory neurons in the adult wing remain intact following an axotomy, instead of being cleared away) can be rescued by clonal Scer\GAL4^VGlut-OK371-driven expression of axed^{Scer\UAS.long}.

(Neukomm et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

axed^{Scer\UAS.long}

axed^UAS.long

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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