FlyBase Allele Report: Dmel\foxo[UAS.cKd]

General Information

Symbol

Dmel\foxo^UAS.cKd

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Koh

FlyBase ID

FBal0318482

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

P{UAS-foxo.Kd}

Key Links

Transgenic product class

cDNA

(Koh et al., 2012)

wild_type

(Koh et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Koh et al., 2012)

wild_type

(Koh et al., 2012)

Mutagen

in vitro construct

(Koh et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-foxo.Kd}

Cytology

Description

UAS regulatory sequences drive expression of a foxo cDNA.

(Koh et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

foxo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Koh et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

foxo^UAS.cKd/Scer\GAL4^hs.PU is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Koh et al., 2012)

foxo^UAS.cKd/Scer\GAL4^hs.PU is a suppressor | partially of increased cell death | adult stage phenotype of Pink1^B9

(Koh et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

foxo^UAS.cKd/Scer\GAL4^hs.PU is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Koh et al., 2012)

foxo^UAS.cKd/Scer\GAL4^hs.PU is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Koh et al., 2012)

foxo^UAS.cKd/Scer\GAL4^hs.PU is a suppressor | partially of indirect flight muscle cell phenotype of Pink1^B9

(Koh et al., 2012)

foxo^UAS.cKd/Scer\GAL4^hs.PU is a suppressor | partially of wing blade phenotype of Pink1^B9

(Koh et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of foxo^Scer\UAS.cKd driven by Scer\GAL4^hs.PU partially suppresses phenotypes (collapsed thorax, downturned wings, swollen mitochondria along with increased cell death and reduced levels of mtDNA and ATP in the indirect flight muscle and locomotor defects) seen in (3 day old) Pink1^B9/Y flies.

(Koh et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

foxo^Scer\UAS.cKd

foxo^UAS.cKd

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Koh

Secondary FlyBase IDs

References (1)

Report Sections

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