FlyBase Allele Report: Fmer\RpL10A[UAS.cWa]

General Information

Symbol

Fmer\RpL10A^UAS.cWa

Species

F. merguiensis

Name

FlyBase ID

FBal0321268

Feature type

allele

Associated gene

Fmer\RpL10A

Associated Insertion(s)

Carried in Construct

P{UAS-shrimpRpL10A.W}

Transgenic product class

wild_type

(Wonglapsuwan et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wonglapsuwan et al., 2011)

Mutagen

in vitro construct

(Wonglapsuwan et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-shrimpRpL10A.W}

Cytology

Description

UAS regulatory sequences drive expression of Fmer\RpL10A coding sequences.

(Wonglapsuwan et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Fmer\RpL10A

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

egg chamber, with Scer\GAL4^{VP16.nanos.UTR}

(Wonglapsuwan et al., 2011)

eye, with Scer\GAL4^GMR.PFa

(Wonglapsuwan et al., 2011)

nurse cell, with Scer\GAL4^{VP16.nanos.UTR}

(Wonglapsuwan et al., 2011)

ommatidium, with Scer\GAL4^GMR.PFa

(Wonglapsuwan et al., 2011)

pigment cell, with Scer\GAL4^GMR.PFa

(Wonglapsuwan et al., 2011)

Detailed Description

Statement

Reference

Expression of Zzzz\RpL10A^Scer\UAS.cWa in the germline, under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} results in mid-stage degeneration. Nurse cells are condensed and surrounded by normal follicle cells, whereas their siblings show normal healthy egg chambers.

Expression of Zzzz\RpL10A^Scer\UAS.cWa in the developing eye, under the control of Scer\GAL4^GMR.PFa results in abnormal ommatidia with a loss of red pigment in the centre of the eyes.

(Wonglapsuwan et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fmer\RpL10A^UAS.cWa/Scer\GAL4^Act5C.PI is a suppressor | partially of lethal - all die before end of larval stage phenotype of RpL10Ab^c03865

(Wonglapsuwan et al., 2011)

Fmer\RpL10A^UAS.cWa/Scer\GAL4^arm.PS is a suppressor | partially of lethal - all die before end of larval stage phenotype of RpL10Ab^c03865

(Wonglapsuwan et al., 2011)

Fmer\RpL10A^UAS.cWa/Scer\GAL4^Act5C.PI is a suppressor | partially of lethal - all die before end of larval stage phenotype of RpL10Ab^CB02653

(Wonglapsuwan et al., 2011)

Fmer\RpL10A^UAS.cWa/Scer\GAL4^arm.PS is a suppressor | partially of lethal - all die before end of larval stage phenotype of RpL10Ab^CB02653

(Wonglapsuwan et al., 2011)

Fmer\RpL10A^UAS.cWa/Scer\GAL4^Act5C.PI is a suppressor | partially of lethal - all die before end of larval stage phenotype of RpL10Ab^KG09231

(Wonglapsuwan et al., 2011)

Fmer\RpL10A^UAS.cWa/Scer\GAL4^arm.PS is a suppressor | partially of lethal - all die before end of larval stage phenotype of RpL10Ab^KG09231

(Wonglapsuwan et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Ubiquitous expression of Zzzz\RpL10A^Scer\UAS.cWa under the control of Scer\GAL4^Act5C.PI, leads to 37%, 16% and 31% viability of the RpL10Ab^CB02653, RpL10Ab^KG09231 and RpL10Ab^c03865 alleles, respectively, whereas expression under the control of Scer\GAL4^arm.PS leads to 39%, 38% and 38% for RpL10Ab^CB02653, RpL10Ab^KG09231 and RpL10Ab^c03865 alleles respectively. In addition, these rescued flies are fertile, indicating that Zzzz\RpL10A^Scer\UAS.cWa has functional conservation with RpL10Ab.

(Wonglapsuwan et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Fmer\RpL10A^Scer\UAS.cWa

Fmer\RpL10A^UAS.cWa

Zzzz\RpL10A^Scer\UAS.cWa

Name Synonyms

Secondary FlyBase IDs

FBal0320654
FBal0284709

References (3)

Report Sections

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