FB2025_01 , released February 20, 2025
Allele: Dmel\Hsp60BVDRC.cUa
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General Information
Symbol
Dmel\Hsp60BVDRC.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0323803
Feature type
allele
Associated gene
Dmel\Hsp60B
Associated Insertion(s)
Carried in Construct
P{VDRC.Hsp60B.U}
Key Links
Transgenic product class
RNAi_reagent
(Deng et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Deng et al., 2015)
Mutagen
in vitro construct
(Deng et al., 2015)
Progenitor genotype
Carried in construct
P{VDRC.Hsp60B.U}
Cytology
Description

UAS regulatory sequences drive expression of a Hsp60B RNAi construct.

(Deng et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsp60B
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hsp60BVDRC.cUa, Scer\GAL4GMR.PU is a suppressor | partially of eye | adult stage phenotype of Hsap\FUSWT.UAS.RFP(Unk),Tag:HA, Scer\GAL4GMR.PU

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4GMR.PU is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\FUSWT.UAS.RFP(Unk),Tag:HA, Scer\GAL4GMR.PU

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4Toll-6-D42 is a suppressor | partially of mitochondrion | third instar larval stage phenotype of Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA, Scer\GAL4Toll-6-D42

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4GMR.PU is a suppressor | partially of interommatidial bristle phenotype of Hsap\FUSWT.UAS.RFP(Unk),Tag:HA, Scer\GAL4GMR.PU

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4GMR.PU is a suppressor | partially of eye | adult stage phenotype of Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA, Scer\GAL4GMR.PU

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4GMR.PU is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA, Scer\GAL4GMR.PU

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4GMR.PU is a suppressor | partially of interommatidial bristle phenotype of Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA, Scer\GAL4GMR.PU

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4Toll-6-D42 is a suppressor | partially of motor neuron | third instar larval stage phenotype of Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA, Scer\GAL4Toll-6-D42

      (Deng et al., 2015)

      Hsp60BVDRC.cUa, Scer\GAL4Toll-6-D42 is a suppressor | partially of axon | third instar larval stage phenotype of Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA, Scer\GAL4Toll-6-D42

      (Deng et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The adult eye phenotype (rough surface due to ommatidial fusion and disorganization of interommatidial bristle pattern, pigmentation loss) characteristic for flies expressing either Hsap\FUSWT.Scer\UAS.T:Disc\RFP,T:Ivir\HA1 or Hsap\FUSP525L.Scer\UAS.T:Disc\RFP,T:Ivir\HA1 under the control of Scer\GAL4GMR.PU is partially rescued by co-expression of Hsp60BVDRC.cUa.

      The decreased size of axonal mitochondria in motor neurons as well as the locomotor defects (tail paralysis) observed in third instar larvae expressing Hsap\FUSP525L.Scer\UAS.T:Disc\RFP,T:Ivir\HA1 under the control of Scer\GAL4Toll-6-D42 or Scer\GAL4VGlut-OK371, respectively, is also significantly improved by co-expression of Hsp60BVDRC.cUa.

      (Deng et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsp60BVDRC.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)