FB2025_01 , released February 20, 2025
Allele: Dmel\gloRNAi.UAS.cUa
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General Information
Symbol
Dmel\gloRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0335387
Feature type
allele
Associated gene
Dmel\glo
Associated Insertion(s)
Carried in Construct
P{UAS-glo.RNAi.U}
Key Links
Transgenic product class
RNAi_reagent
(Gehrke et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Gehrke et al., 2015)
Mutagen
in vitro construct
(Gehrke et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-glo.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of an RNAi line that targets glo.

(Gehrke et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
glo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of glodsRNA.Scer\UAS.cUa does not lead to wing posture or jumping ability defects (with the Scer\GAL4Mhc.PU driver) and neither does it induce abnormal mitochondrial aggregations in dopaminergic (DA) neurons or loss of PPL1 cluster DA neurons in the adult brain (with the Scer\GAL4ple.PF driver).

      (Gehrke et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abnormal mitochondrial aggregations (observed in flight muscles or dopaminergic neurons), wing posture and jumping ability defects as well as the loss of dopaminergic neurons from the PPL1 cluster characteristic for Pink1B9 adult homozygotes are significantly improved by expression (controlled by either the Scer\GAL4Mhc.PU muscle driver or the Scer\GAL4ple.PF neuronal driver) of glodsRNA.Scer\UAS.cUa. Similarly, the abnormal mitochondrial morphology in the flight muscles of adult flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PU is partially suppressed by co-expression of glodsRNA.Scer\UAS.cUa.

      (Gehrke et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      gloRNAi.UAS.cUa
      glodsRNA.Scer\UAS.cUa
      glodsRNA.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)