FlyBase Allele Report: Zzzz\poly-GR[36.UAS.EGFP]

General Information

Symbol

Zzzz\poly-GR^36.UAS.EGFP

Species

a. artificial

Name

FlyBase ID

FBal0344198

Feature type

allele

Associated gene

Zzzz\poly-GR

Associated Insertion(s)

Carried in Construct

P{UAS-EGFP-GR36}

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Xu and Xu, 2018)

Progenitor genotype

Carried in construct

P{UAS-EGFP-GR36}

Cytology

Description

UASt regulatory sequences drive expression of 36 copies of a GR dipeptide repeat, tagged with EGFP.

(Xu and Xu, 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Zzzz\poly-GR

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEC

(Xu et al., 2019)

CEA

(Xu and Xu, 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by Upf1^UASp.GFP

(Xu et al., 2019)

is ameliorated by Upf2^UAS.cAa

(Xu et al., 2019)

is ameliorated by VGlut1^HMS02011

(Xu and Xu, 2018)

is ameliorated by VGlut1^HMS02175

(Xu and Xu, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult antennal lobe, with Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

adult motor neuron, with Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

Detailed Description

Statement

Reference

Adults expressing Zzzz\poly-GR^36.UAS.EGFP under the control of Scer\GAL4^Toll-6-D42 show loss of motor neurons in the antennal lobe and present a significant decrease in climbing ability, as compared to controls.

(Xu et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has short lived phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Arc1^JF01974, Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has short lived phenotype, suppressible by Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has short lived phenotype, suppressible | partially by Upf2^UAS.cAa/Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has decreased cell number | adult stage phenotype, suppressible | partially by Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Upf2^UAS.cAa/Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has adult antennal lobe phenotype, suppressible | partially by Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP has adult motor neuron phenotype, suppressible | partially by Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP

(Xu et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Zzzz\poly-GR^36.UAS.EGFP

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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