FlyBase Allele Report: Hsap\TARDBP[CTR.UAS]

General Information

Symbol

Hsap\TARDBP^CTR.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0356511

Feature type

allele

Associated gene

Hsap\TARDBP

Associated Insertion(s)

Carried in Construct

P{UAS-hTARDBP.CTR}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Donde et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-hTARDBP.CTR}

Cytology

Description

UASt regulatory sequences drive expression of a chimeric protein composed of amino acids 1-267 of Hsap\TARDBP fused to amino acids 450-643 (the splicing repression domain) of the mouse Raver1 gene (MGI:MGI:1919016).

(Donde et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\TARDBP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 10

modeled by TBPH^Δ23

(Donde et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42/Hsap\TARDBP^CTR.UAS is a suppressor | partially of short lived phenotype of TBPH^Δ23

(Donde et al., 2019)

Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS is a suppressor | partially of short lived phenotype of TBPH^Δ23

(Donde et al., 2019)

Scer\GAL4^Toll-6-D42/Hsap\TARDBP^CTR.UAS is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of TBPH^Δ23

(Donde et al., 2019)

Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of TBPH^Δ23

(Donde et al., 2019)

Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of TBPH^Δ23

(Donde et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of TBPH^Δ23

(Donde et al., 2019)

Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS is a suppressor | partially of NMJ bouton | third instar larval stage phenotype of TBPH^Δ23

(Donde et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\TARDBP^CTR.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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