FlyBase Allele Report: Dmel\Dys[Dp186.UAS]

General Information

Symbol

Dmel\Dys^Dp186.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0362066

Feature type

allele

Associated gene

Dmel\Dys

Associated Insertion(s)

Carried in Construct

P{UAS-Dys.Dp186}

Also Known As

UAS-Dp186

Key Links

Transgenic product class

wild_type

(Fradkin et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Fradkin et al., 2008)

Mutagen

in vitro construct

(Fradkin et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-Dys.Dp186}

Cytology

Description

UASt regulatory sequences drive expression of the full-length Dys Dp186 isoform.

(Fradkin et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Dys

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology, with Scer\GAL4^eve.RN2

(Fradkin et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Dys^{Dp186.Scer\UAS} postsynaptically, under the control of Scer\GAL4^eve.RN2, results in significant potentiation of synaptic currents.

(Fradkin et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Dys^Dp186.UAS, Scer\GAL4^eve.RN2 has abnormal neurophysiology phenotype, non-enhanceable by gbb¹

(Fradkin et al., 2008)

NOT suppressed by

Statement

Reference

Dys^Dp186.UAS, Scer\GAL4^eve.RN2 has abnormal neurophysiology phenotype, non-suppressible by gbb¹

(Fradkin et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

A gbb¹ heterozygous or homozygous background has no effect on the increase in synaptic current amplitude found upon expression of Dys^{Dp186.Scer\UAS} post-synaptically under the control of Scer\GAL4^eve.RN2.

(Fradkin et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Dys^Dp186.UAS/Scer\GAL4^GH146 rescues Dys^Dp186.166.3

(Jantrapirom et al., 2019)

Dys^Dp186.UAS/Scer\GAL4^SG18.1 rescues Dys^Dp186.166.3

(Jantrapirom et al., 2019)

Scer\GAL4^elav.PU/Dys^Dp186.UAS rescues Dys^Dp186.166.3

(Jantrapirom et al., 2019)

Scer\GAL4^eve.RN2/Dys^Dp186.UAS rescues Dys^Dp186.166.3

(Fradkin et al., 2008)

Fails to rescue

Dys^Dp186.UAS/Scer\GAL4^ChAT.7.4 fails to rescue Dys^Dp186.166.3

(Fradkin et al., 2008)

Comments

Overexpression of Dys^Dp186.UAS in the postsynaptic aCC/RP2 motor neurons (under the control of Scer\GAL4^eve.RN2 rescues the Dys^Dp186.166.3 action potential-dependent synaptic current amplitude phenotype. Expression in the presynaptic cholinergic interneurons under the control of Scer\GAL4^ChAT.7.4 does not rescue the increased amplitude.

(Fradkin et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dys^{Dp186.Scer\UAS}

Dys^Dp186.UAS

Dys^{F.Dp186.Scer\UAS}

Dys^F.Dp186.UAS

det^{Dp186.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

FBal0246201
FBal0216504

References (4)

Report Sections

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