UASt regulatory sequences drive expression of a Ogdh cDNA, mutated to carry a R316G amino acid replacement, and tagged with Tag:FLAG. The mutation is equivalent to a R299G change in the orthologous human OGDHL gene, a variant identified in an individual with bi-allelic variants in the OGDHL gene and with a range of neurological and neurodevelopmental phenotypes.
C16962798G
R307G | Ogdh1-PA; R307G | Ogdh1-PB; R307G | Ogdh1-PC; R316G | Ogdh1-PF; R307G | Ogdh1-PG; R316G | Ogdh1-PH; R307G | Ogdh1-PI; R307G | Ogdh1-PJ; R309G | Ogdh1-PK
R316G
Analogous R299G mutation in human OGDHL implicated in neurodegenerative disease, OGDHL-related; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.